Hepatitis C virus NS4B targets lipid droplets through hydrophobic residues in the amphipathic helices
نویسندگان
چکیده
منابع مشابه
Hepatitis C virus NS4B targets lipid droplets through hydrophobic residues in the amphipathic helices.
Lipid droplets (LD) are dynamic storage organelles that are involved in lipid homeostasis. Hepatitis C virus (HCV) is closely associated with LDs. HCV Core and nonstructural (NS) proteins colocalize with LDs and presumably are involved in virion formation at that site. We demonstrated that HCV NS4B, an integral membrane protein in endoplasmic reticulum (ER), strongly targeted LDs. Confocal imag...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2013
ISSN: 0022-2275
DOI: 10.1194/jlr.m026443